Fundamentals of Nuclear Pharmacy by Gopal B. Saha

Author:Gopal B. Saha
Language: eng
Format: epub, pdf
Publisher: Springer International Publishing, Cham

Other organs

1.5

400.0

133Xe-xenon

Lungs

0.008

2.2

223Ra-radium chloride (Xofigo)

Osteogenic cells

Red marrow

Bladder wall

Lower intestine wall

Liver

Kidneys

4262.6

513.5

14.9

171.9

11.0

11.9

1.15 × 106

1.4 × 105

4030.0

4.6 × 104

2980.0

3200.0

aFrom Stabin et al. (1996)

bFrom Wiseman et al. (2003)

10.2.3 Effective Dose Equivalent and Effective Dose

The concept of effective dose equivalent has been introduced by the International Commission on Radiation Protection (ICRP) because the stochastic damaging effects of radiations vary in different tissues. While the dose equivalent (H r) is related to the variations of damage caused by types of radiations, the effective dose equivalent (H T) relates to the damage caused by the radiosensitivity of different tissues. Dimensionless weighting factors (W T) have been assigned to different organs based on their relative radiosensitivities that were assessed from the expression of cancer and genetic defects in various populations exposed to radiation. The tissue-weighted dose equivalent (H T) to an organ or tissue is given by the product of the dose equivalent (H r) to the organ or tissue and the W T applicable to that organ or tissue. Thus,

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